Fourth-graders Drake Doyle and Nell Fossey combine their detective and scientific investigation skills to solve cases involving a crooked carnival barker, a mysterious ghost, an alien plant species invading wildlife habitats, and a wobbly bridge.

Fifth-grade sleuths and science experts Drake and Nell solve four challenging cases involving a werewolf at a campsite, a faked tyrannosaurus rex skeleton, a talking oven, and a polluted stream full of dead fish.

In 1519, after the death of his parents, fourteen-year-old Mateo Macias becomes cabin boy to Ferdinand Magellan on a dangerous journey in search of a route to the fabled Spice Islands.